Diagnosis of bacterial infections and parasitic infestations in salt and freshwater fish is very difficult even for the most advanced aquarist. While no drug is 100% effective, the aquarist should not hestitate to try other medication products.
What appears to be the same disease on different fish, or on the same affliction. Antibiotics can be effective against one and not the other.
Visable Physical Symptoms
Symptoms - Probable Cause
Small white spots on fins or skin - White spot (Cryptocaryon)
Fine whitish peppery coating on fins or skin - Velvet (Amyloodinium)
Spawn-like gray-white patches on fins or skin - Lymphocystis
Cauliflower-like patches on fins or skin - Lymphocystis (later stage)
Larger "tapioca" patches on fins of skin - Myxosporiasis (Henneguya)
Blue-white or pinkish patches on skin - Ciliates
Red streaks on body or fins - Bacterial septicemia
Tattered fins or tail (fin or tail-rot) - Bacterial septicemia (later stage)
Red-ringed craters on skin - Argulus bites
Irregular bulges (cysts) under skin - Microporiasis
Swellings on body or base of fins - Tumors or Sporozoans
Yellow-to-black cysts up to 1/5 in. bursting through body - Ichthyophonus - White spot disease is caused by a parasite that attacks all freshwater and saltwater fish species. The fish appears to be covered by numerous white spots. The parasite is easily transmitted from one fish to another. Ich can only be controlled in the free-swimming stage of the parasite. Five to 30 days may be needed before the infestation is completely eradicated.
White to dark nodules under skin - Larval tapeworm (Cestoda)
Black or reddish nodules under skin or in eyes - Metacercaria
Ulcerated patches on skin - Bacterial septicemia or Ichthyophonus
Cloudy skin and gils, blood flecks - pH too extreme
Blisters beneath skin - Gas embolish
Cloudy eyes or blindness - Severe velvet or white spot, metacercaria, toxins
Sunken eyes - Chlorine excess, dropsy
Exophthalmos (pop-eye) - Gas embolism, toxins, copper, some diseases
Lateral line erosion - Lateral line disease (viral?)
Emaciation, paleness, perhaps skin ulcers - Tuberculosis, Nocardia, or Tripanoplasmiasis
Emaciation, paleness, light-colored or bloody feces - Coccidiosis
Emaciation, swollen belly, odd movements - Cestoda (tapeworms)
Red and swollen gills with gray or white spots - Bacterial gill disease
Brown gills - Nitrite poisoning
Eroded or tattered gills - Chlorine poisoning
Gill covers protruding - Gill parasites, goiter, velvet
Swollen body, often scales protruding - Dropsy, intestinal blockage
Scales protruding, body normal - Bacterial infection of scales
Flukes about 1/5", fins perhaps torn - Benedenia
Flukes 1/25" or less on gills or body - Gyrodactylus, etc.
Large "lice" up to 1/5" on skin - Argulus
Wood - louse - like crustacea in mouth or on skin - Isopods
Threadworms hanging from anus - Nematodes
Egg-sacs hanging from gills or body - Copepods
Hemorrhages, spinal curvature, pop-eye, cloudy eyes, convolsions (2 or more of these together) - Vitamin deficiency
Behavioral Symptoms
Flashing, fins clamped - Velvet, white spot, toxins
Listlessness, loss of balance - Sleeping sickness, metallic poisoning, chill
Swimming on the spot (Shimmies) - Velvet, chill
Severe loss of balance, belly up - Swim bladder disease
Gasping at surface - Oxygen lack, toxins, gill diseases, tank overheated
Sudden dashes, jumping out of tank - pH wrong, toxins
Unusual colors, especially dark - Toxins, Ichthyophonus
Failure to eat - Stress, wrong food, various diseases
Smears of Skin or Gills
Small flukes - Benedenia larvae, Gyrodactylus, etc.
Pear-shaped flagellate - Velvet (Amyloodinium)
Ciliates:
Ovoid, no hooks - White spot (Cryptocaryon)
Ring of hooks - Trichodina - An external parasite most commonly found in freshwater fish, causing cloudiness on the skin and red areas where hemorrhages have occurred due to the teeth of the parasite.
Heart-shaped or oval, no hooks - Brooklynella or Chilodonella - An external parasite causing the fish to secrete excess mucous, resulting in the appearance of a bluish-white film on the body of the fish. In severe conditions, the skin peels off, gills are damaged and the fish dies. Gills are usually attacted first and symptoms of oxygen starvation are noted.
Single stalked ciliate - Trichophrya, Glossatella, etc.
Branching stalks - Epistylis